Abstract: Cities in the Pearl River Delta area are generally affected by climate change and urban expansion. As a component of the Pearl River Delta micro-city cluster, central and eastern Pazhou of Guangzhou is the carrier of the Pearl River Delta evolutionary resilience. The paper takes it as an example to explore the resilience design mechanism for integrating urban and ecological environments. Firstly, it discriminates the analysis methods, strategies and evaluation systems of urban resilience, and launches a background research on the Pearl River Delta vulnerabilities. Secondly, with the vulnerability analysis and disaster simulation of central and eastern Pazhou, it puts forward three levels of resilience integration strategies, including the structural strategy to connect the existing fragmented blue-green systems, construct the walking accessible space connection mode based on transit-oriented development (TOD) and vertical waterfront, distributed rain water storage system, and the node processing for multi-purpose embankment model. Lastly, with the software platform of GIS, Fragstats and Depthmap, and data analysis means, it evaluates and gives feedback on the resilience strategy and design scheme, so as to construct a whole-process resilient urban design mechanism featuring “analysis – strategy - scheme - feedback” for the micro-city cluster. The result shows that the resilient urban design based on the “strategy - feedback” mechanism helps to improve the landscape connectivity and spatial integration, effectively adapt to the flood interference, and better implement urban resilience.